CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Complement factor D |
Enzyme Information
| 3.4.21.78 |
Granzyme A.
based on mapping to UniProt P12544
Hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: -Arg-|-Xaa-, -Lys-|-Xaa- >> -Phe-|- Xaa- in small molecule substrates.
-!- From cytotoxic T lymphocyte granules. -!- The human enzyme does not cleave Phe-|-Xaa. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P12544 |
GRAA_HUMAN
Homo sapiens
Granzyme A
|
PDB Structure
| PDB | 1ORF |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity.
Nat.Struct.Biol.
|
