CATH Domain 1mjfB01

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CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.140	Spermidine Synthase; Chain: A, domain 2
	2.30.140.10	Spermidine synthase, tetramerisation domain

Domain Context

CATH Clusters

Superfamily	Spermidine synthase, tetramerisation domain
Functional Family	Polyamine aminopropyltransferase

Enzyme Information

2.5.1.104	N(1)-aminopropylagmatine synthase. based on mapping to UniProt Q8U4G1 S-adenosylmethioninamine + agmatine = S-methyl-5'-thioadenosine + N(1)- (3-aminopropyl)agmatine. -!- The enzyme is involved in the biosynthesis of spermidine from agmatine in some archaea and bacteria. -!- The enzyme from the Gram-negative bacterium Thermus thermophilus accepts agmatine, spermidine and norspermidine with similar catalytic efficiency. -!- The enzymes from the archaea Pyrococcus furiosus and Thermococcus kodakarensis prefer agmatine, but can utilize cadaverine, putrescine and propane-1,3-diamine with much lower catalytic efficiency. -!- Cf. EC 2.5.1.16 and EC 2.5.1.23.
2.5.1.-	Transferring alkyl or aryl groups, other than methyl groups. based on mapping to UniProt Q8U4G1
2.5.1.16	Spermidine synthase. based on mapping to UniProt Q8U4G1 S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine. -!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.
2.5.1.23	Sym-norspermidine synthase. based on mapping to UniProt Q8U4G1 S-adenosyl 3-(methylthio)propylamine + propane-1,3-diamine = S-methyl- 5'-thioadenosine + bis(3-aminopropyl)amine. -!- The enzyme has been originally characterized from the protist Euglena gracilis. -!- The enzyme from the archaeon Sulfolobus solfataricus can transfer the propylamine moiety from S-adenosyl 3-(methylsulfanyl)propylamine to putrescine, sym-norspermidine and spermidine with lower efficiency. -!- Cf. EC 2.5.1.16 and EC 2.5.1.22.

UniProtKB Entries (1)

SPEE_PYRFU

Pyrococcus furiosus DSM 3638

Polyamine aminopropyltransferase

PDB Structure

PDB	1MJF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	PUTATIVE SPERMIDINE SYNTHETASE FROM PYROCOCCUS FURIOSUS PFU-132382 Southeast Collaboratory for Structural Genomics to be published