CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | alpha/beta hydrolase |
Domain Context
CATH Clusters
| Superfamily | alpha/beta hydrolase |
| Functional Family | Pimeloyl-[acyl-carrier protein] methyl ester esterase |
Enzyme Information
| 3.1.1.85 |
Pimeloyl-[acyl-carrier protein] methyl ester esterase.
based on mapping to UniProt P13001
Pimeloyl-[acyl-carrier protein] methyl ester + H(2)O = pimeloyl-[acyl- carrier protein] + methanol.
-!- Involved in biotin biosynthesis in Gram-negative bacteria. -!- The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains. -!- Even though the enzyme can interact with coenzyme A thioesters, the in vivo role of the enzyme is to hydrolyze the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalyzed by the fatty acid elongation enzymes.
|
UniProtKB Entries (1)
| P13001 |
BIOH_ECOLI
Escherichia coli K-12
Pimeloyl-[acyl-carrier protein] methyl ester esterase
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PDB Structure
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| Primary Citation |
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