CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.20 | Alpha-Beta Barrel |
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3.20.20 | TIM Barrel |
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3.20.20.100 | NADP-dependent oxidoreductase domain |
Domain Context
CATH Clusters
Superfamily | NADP-dependent oxidoreductase domain |
Functional Family | Aldo-keto reductase family 1 member C3 |
Enzyme Information
1.3.1.20 |
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase.
based on mapping to UniProt P52895
Trans-1,2-dihydrobenzene-1,2-diol + NADP(+) = catechol + NADPH.
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1.1.1.357 |
3-alpha-hydroxysteroid 3-dehydrogenase.
based on mapping to UniProt P52895
A 3-alpha-hydroxysteroid + NAD(P)(+) = a 3-oxosteroid + NAD(P)H.
-!- The enzyme acts on multiple 3-alpha-hydroxysteroids, such as androsterone and 5 alpha-dihydrotestosterone. -!- The mammalian enzymes are involved in inactivation of steroid hormones, while the bacterial enzymes are involved in steroid degradation. -!- This entry stands for enzymes whose stereo-specificity with respect to NAD(+) or NADP(+) is not known (cf. EC 1.1.1.50 and EC 1.1.1.213).
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1.-.-.- |
Oxidoreductases.
based on mapping to UniProt P52895
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UniProtKB Entries (1)
P52895 |
AK1C2_HUMAN
Homo sapiens
Aldo-keto reductase family 1 member C2
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PDB Structure
PDB | 1J96 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.
J.Biol.Chem.
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