CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Estradiol 17-beta-dehydrogenase 1 |
Enzyme Information
| 1.1.1.62 |
17-beta-estradiol 17-dehydrogenase.
based on mapping to UniProt P14061
17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
-!- The enzyme oxidizes or reduces the hydroxy/keto group on C(17) of estrogens and androgens in mammals and regulates the biological potency of these steroids. -!- The mammalian enzyme is bifunctional and also catalyzes EC 1.1.1.270. -!- The enzyme also acts on (S)-20-hydroxypregn-4-en-3-one and related compounds, oxidizing the (S)-20-group, but unlike EC 1.1.1.149, it is Si-specific with respect to NAD(P)(+).
|
UniProtKB Entries (1)
| P14061 |
DHB1_HUMAN
Homo sapiens
Estradiol 17-beta-dehydrogenase 1
|
PDB Structure
| PDB | 1FDT |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors.
Structure
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