CATH Domain 1f0pA00

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Diacylglycerol acyltransferase/mycolyltransferase Ag85C

Enzyme Information

2.3.1.20	Diacylglycerol O-acyltransferase. based on mapping to UniProt P9WQP1 Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol. -!- Palmitoyl-CoA and other long-chain acyl-CoAs can act as donors.
2.3.1.122	Trehalose O-mycolyltransferase. based on mapping to UniProt P9WQP1 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose + alpha,alpha'-trehalose 6,6'-bismycolate. -!- Catalyzes the exchange of mycolic acid between trehalose, trehalose mycolate and trehalose bismycolate. -!- Trehalose 6-palmitate can also act as donor.

UniProtKB Entries (1)

A85B_MYCTU

Mycobacterium tuberculosis H37Rv

Diacylglycerol acyltransferase/mycolyltransferase Ag85B

PDB Structure

PDB	1F0P
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Mycobacterium
Primary Citation	An interfacial mechanism and a class of inhibitors inferred from two crystal structures of the Mycobacterium tuberculosis 30 kDa major secretory protein (Antigen 85B), a mycolyl transferase. Anderson, D.H., Harth, G., Horwitz, M.A., Eisenberg, D. J.Mol.Biol.