CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.20 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.20 |
| Functional Family | D-alanine--D-alanine ligase |
Enzyme Information
| 6.1.2.1 |
D-alanine--(R)-lactate ligase.
based on mapping to UniProt P25051
D-alanine + (R)-lactate + ATP = D-alanyl-(R)-lactate + ADP + phosphate.
-!- The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4. -!- The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
|
UniProtKB Entries (1)
| P25051 |
VANA_ENTFC
Enterococcus faecium
Vancomycin/teicoplanin A-type resistance protein VanA
|
PDB Structure
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