CATH Domain 1b0eA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Chymotrypsin-like elastase family member 1

Enzyme Information

3.4.21.36

Pancreatic elastase.

based on mapping to UniProt P00772

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

-!- Formed by activation of proelastase from mammalian pancreas by trypsin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.7 and EC 3.4.21.11.

UniProtKB Entries (1)

P00772

CELA1_PIG

Sus scrofa

Chymotrypsin-like elastase family member 1

PDB Structure

PDB	1B0E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones. Cregge, R.J., Durham, S.L., Farr, R.A., Gallion, S.L., Hare, C.M., Hoffman, R.V., Janusz, M.J., Kim, H.O., Koehl, J.R., Mehdi, S., Metz, W.A., Peet, N.P., Pelton, J.T., Schreuder, H.A., Sunder, S., Tardif, C. J.Med.Chem.