CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.40 | SH3 Domains |
Domain Context
CATH Clusters
| Superfamily | SH3 Domains |
| Functional Family | Tyrosine-protein kinase Fyn |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06241
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (2)
| P03406 |
NEF_HV1BR
Human immunodeficiency virus type 1 (BRU ISOLATE)
Protein Nef
|
| P06241 |
FYN_HUMAN
Homo sapiens
Tyrosine-protein kinase Fyn
|
PDB Structure
| PDB | 1AVZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.
Structure
|