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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 633053: Cobyrinate a,c-diamide synthase

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing). [EC: 6.3.5.11]
2 ATP + cobyrinate + 2 L-glutamine + 2 H(2)O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate.
  • This enzyme is the first glutamine amidotransferase that participates in the anaerobic (early cobalt insertion) biosynthetic pathway of adenosylcobalamin, and catalyzes the ATP-dependent synthesis of cobyrinate a,c-diamide from cobyrinate using either L-glutamine or ammonia as the nitrogen source.
  • It is proposed that the enzyme first catalyzes the amidation of the c-carboxylate, and then the intermediate is released into solution and binds to the same catalytic site for the amidation of the a-carboxylate.
  • The Km for ammonia is substantially higher than that for L-glutamine.
 1814 A0A011A994 A0A011NJR1 A0A011PDE5 A0A011Q4E9 A0A015KPL6 A0A022PKS0 A0A022SU67 A0A023CP60 A0A023DD00 A0A023VF59
(1804 more...)
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing). [EC: 6.3.5.9]
2 ATP + hydrogenobyrinic acid + 2 L-glutamine + 2 H(2)O = 2 ADP + 2 phosphate + hydrogenobyrinic acid a,c-diamide + 2 L-glutamate.
  • This step in the aerobic biosynthesis of cobalamin generates hydrogenobyrinic acid a,c-diamide, the substrate required by EC 6.6.1.2, which adds cobalt to the macrocycle.
 1566 A0A010SRI4 A0A010YJC4 A0A011TE73 A0A011UQ44 A0A017HD16 A0A021X5Z1 A0A022LEM2 A0A023CE53 A0A023X234 A0A023XH73
(1556 more...)
Dethiobiotin synthase. [EC: 6.3.3.3]
ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin.
  • CTP has half the activity of ATP.
 2 A0A0W8JD23 G6EXG1
Cob(II)yrinic acid a,c-diamide reductase. [EC: 1.16.8.1]
2 cob(I)yrinic acid a,c-diamide + FMN + 2 H(+) = 2 cob(II)yrinic acid a,c-diamide + FMNH(2).
  • This enzyme also catalyzes the reduction of cob(II)yric acid, cob(II)inamide, cob(II)inamide phosphate, GDP-cob(II)inamide and cob(II)alamin although cob(II)yrinic acid a,c-diamide is thought to be the physiological substrate.
  • Also uses FAD and NADH but not NADPH.
 1 G2JAL3
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase. [EC: 2.4.2.21]
Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.
  • Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate.
  • The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2.
  • It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.
 1 R6K4Z3
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