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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 633046: Atp-dependent rna helicase dhx8

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
RNA helicase. [EC: 3.6.4.13]
ATP + H(2)O = ADP + phosphate.
  • RNA helicases utilize the energy from ATP hydrolysis to unwind RNA.
  • Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity.
  • Some helicases unwind DNA as well as RNA.
  • May be identical with EC 3.6.4.12 (DNA helicase).
 177 A0A024V8Q0 A0A024VR58 A0A024WRF7 A0A024X896 A0A024X901 A0A060S3X4 A0A061IH30 A0A061II28 A0A077TNP6 A0A077XI90
(167 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 52 A0A0J9TR95 A0A0R3NSM7 A0A151SLV5 A0A151SLY2 A0A151SLY8 A0A151SLZ3 A0A151SUL8 A0A151TBQ5 A1Z9L3 A3LP11
(42 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 34 A0A060T2C7 A0A074SRG7 A0A074T5R7 A0A074TN94 A0A086JFA5 A0A086JRI8 A0A086KIH5 A0A086KWY3 A0A086L3Z4 A0A086L705
(24 more...)
Nuclear-inclusion-a endopeptidase. [EC: 3.4.22.44]
Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
  • The potyviruses cause diseases in plants, and inclusion bodies appear in the host cell nuclei, protein a of these being the endopeptidase.
  • The enzyme finds practical use when encoded in vectors for the artificial expression of recombinant fusion proteins, since it can confer on them the capacity for autolytic cleavage.
  • It is also reported that transgenic plants expressing the enzyme are resistant to viral infection.
  • Belongs to peptidase family C4.
 19 A0A0A1TWN0 B0E818 B0E9C3 B0EAV5 B0ECZ2 B0ED15 B0EE80 B0ES02 B7PAK3 B7QCC2
(9 more...)
Endopeptidase La. [EC: 3.4.21.53]
Hydrolysis of proteins in presence of ATP.
  • ATP hydrolysis is linked with peptide bond hydrolysis.
  • Vanadate inhibits both reactions.
  • A similar enzyme occurs in animal mitochondria.
  • Belongs to peptidase family S16.
 8 A0A0E1C2Q8 A0A172XC93 A1R0Q2 W5SBU0 W5SJT0 W5SPJ4 W5SVS1 W6TH70
Polyribonucleotide nucleotidyltransferase. [EC: 2.7.7.8]
RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.
  • ADP, IDP, GDP, UDP and CDP can act as donors.
 3 A0A084G1S5 B7PAK3 L0B0N2
Quinol--cytochrome-c reductase. [EC: 1.10.2.2]
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
  • The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain.
  • It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria.
  • The mammalian enzyme contains cytochromes b-562, b-566 and C(1), and a 2-iron ferredoxin.
  • Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3).
 1 A0A075AP48
RNA-directed RNA polymerase. [EC: 2.7.7.48]
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
  • Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.
  • Can initiate a chain de novo.
  • See also EC 2.7.7.6.
 1 G0QWU7
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