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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 631079: ABC transporter, ATP-binding component

There are 16 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 53 A0A060SX69 A0A060TAR3 A0A060TD39 A0A085A413 A0A085G186 A0A085G514 A0A085H265 A0A085HBC0 A0A085HCV6 A0A085I5E0
(43 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 24 A0A060TFN6 A0A085A413 A0A085G186 A0A085G514 A0A085H265 A0A085HBC0 A0A085HCV6 A0A085I5E0 A0A085JP27 A0A0N0IBG5
(14 more...)
Heme-transporting ATPase. [EC: 3.6.3.41]
ATP + H(2)O + heme(In) = ADP + phosphate + heme(Out).
  • An enzyme found in Gram-negative bacteria that exports heme.
 20 A0A023B408 A0A074T5A4 A0A086JFZ7 A0A086JVR1 A0A086KGR4 A0A086PR99 A0A086PUN2 A0A0E2Z4H2 A0A0F7URF8 A0A125YVQ3
(10 more...)
Phosphonate-transporting ATPase. [EC: 3.6.3.28]
ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In).
  • A bacterial enzyme that imports phosphonate and organophosphate anions.
 8 A0A0U5IGR1 A0A160S4E2 A0A160SL77 A0A161MKS1 B0EIP1 B0EIX5 D6CU53 E0V979
Molybdate-transporting ATPase. [EC: 3.6.3.29]
ATP + H(2)O + molybdate(Out) = ADP + phosphate + molybdate(In).
  • A bacterial enzyme that imports molybdate anions.
 8 A0A0U5F6A3 A0A0U5FJV8 A0A0X8R6J3 B7RQU2 D5BNA3 D5RHS5 H6SQY4 Q2RSC5
Fe(3+)-transporting ATPase. [EC: 3.6.3.30]
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
  • A bacterial enzyme that imports ferric cations.
 6 A0A0F4FV20 B6AXS2 G0AJI1 G9A362 Q39F27 Q3SS07
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 6 A0A0U5IGR1 A0A160S4E2 A0A160SL77 A0A1J0NQW2 D6CU53 I2B105
Proteasome endopeptidase complex. [EC: 3.4.25.1]
Cleavage of peptide bonds with very broad specificity.
  • A 20-S protein composed of 28 subunits arranged in four rings of seven.
  • The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity.
  • In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities.
  • The molecule is barrel-shaped, and the active sites are on the inner surfaces.
  • Terminal apertures restrict access of substrates to the active sites.
  • Inhibited by mercurial reagents and some inhibitors of serine endopeptidases.
  • Belongs to peptidase family T1.
  • Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46.
 2 A0A1L0D7M5 A0A1L0FZS2
Monosaccharide-transporting ATPase. [EC: 3.6.3.17]
ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
  • Family of bacterial enzymes importing ribose, xylose, arabinose, galactose and methylgalactoside.
 1 A0A084G6K4
Histidine kinase. [EC: 2.7.13.3]
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.
  • This entry has been included to accommodate those protein-histidine kinases for which the phosphorylation site has not been established (i.e. either the pros- or tele-nitrogen of histidine).
  • A number of histones can act as acceptor.
 1 U2ERL5
Isocitrate lyase. [EC: 4.1.3.1]
Isocitrate = succinate + glyoxylate.
  • The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3- tricarboxylate.
 1 B8M4M3
Beta-glucan-transporting ATPase. [EC: 3.6.3.42]
ATP + H(2)O + beta-glucan(In) = ADP + phosphate + beta-glucan(Out).
  • An enzyme found in Gram-negative bacteria that exports beta-glucan.
 1 A0A084GEH9
Teichoic-acid-transporting ATPase. [EC: 3.6.3.40]
ATP + H(2)O + teichoic acid(In) = ADP + phosphate + teichoic acid(Out).
  • An enzyme found in Gram-positive bacteria that exports teichoic acid.
 1 A0A084GEH9
Sulfate-transporting ATPase. [EC: 3.6.3.25]
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
  • A bacterial enzyme that imports sulfate and thiosulfate anions.
 1 A0A084G6K4
Phosphate-transporting ATPase. [EC: 3.6.3.27]
ATP + H(2)O + phosphate(Out) = ADP + phosphate + phosphate(In).
  • A bacterial enzyme that imports phosphate anions.
 1 B0EIP1
DNA topoisomerase (ATP-hydrolyzing). [EC: 5.99.1.3]
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
  • Can introduce negative superhelical turns into double-stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
 1 A0A0C9W1K7
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