CATH Domain 6c3eB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13546

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13546

RIPK1_HUMAN

Homo sapiens

Receptor-interacting serine/threonine-protein kinase 1

PDB Structure

PDB	6C3E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. Yoshikawa, M., Saitoh, M., Katoh, T., Seki, T., Bigi, S.V., Shimizu, Y., Ishii, T., Okai, T., Kuno, M., Hattori, H., Watanabe, E., Saikatendu, K.S., Zou, H., Nakakariya, M., Tatamiya, T., Nakada, Y., Yogo, T. J. Med. Chem.