CATH Domain 6bwkA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Mixed lineage kinase domain-like pseudokinase

Enzyme Information

UniProtKB Entries (1)

MLKL_HUMAN

Homo sapiens

Mixed lineage kinase domain-like protein

PDB Structure

PDB	6BWK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis. Petrie, E.J., Sandow, J.J., Jacobsen, A.V., Smith, B.J., Griffin, M.D.W., Lucet, I.S., Dai, W., Young, S.N., Tanzer, M.C., Wardak, A., Liang, L.Y., Cowan, A.D., Hildebrand, J.M., Kersten, W.J.A., Lessene, G., Silke, J., Czabotar, P.E., Webb, A.I., Murphy, J.M. Nat Commun