CATH Domain 5orsA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Aurora kinase A

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt O14965

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965

AURKA_HUMAN

Homo sapiens

Aurora kinase A

PDB Structure

PDB	5ORS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches. McIntyre, P.J., Collins, P.M., Vrzal, L., Birchall, K., Arnold, L.H., Mpamhanga, C., Coombs, P.J., Burgess, S.G., Richards, M.W., Winter, A., Veverka, V., Delft, F.V., Merritt, A., Bayliss, R. ACS Chem. Biol.