CATH Domain 5kcvA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P31749

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31749

AKT1_HUMAN

Homo sapiens

RAC-alpha serine/threonine-protein kinase

PDB Structure

PDB	5KCV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor. Lapierre, J.M., Eathiraj, S., Vensel, D., Liu, Y., Bull, C.O., Cornell-Kennon, S., Iimura, S., Kelleher, E.W., Kizer, D.E., Koerner, S., Makhija, S., Matsuda, A., Moussa, M., Namdev, N., Savage, R.E., Szwaya, J., Volckova, E., Westlund, N., Wu, H., Schwartz, B. J.Med.Chem.