CATH Domain 5ct7B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	B-Raf proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P15056

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056

BRAF_HUMAN

Homo sapiens

Serine/threonine-protein kinase B-raf

PDB Structure

PDB	5CT7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of RAF265: A Potent mut-B-RAF Inhibitor for the Treatment of Metastatic Melanoma. Williams, T.E., Subramanian, S., Verhagen, J., McBride, C.M., Costales, A., Sung, L., Antonios-McCrea, W., McKenna, M., Louie, A.K., Ramurthy, S., Levine, B., Shafer, C.M., Machajewski, T., Renhowe, P.A., Appleton, B.A., Amiri, P., Chou, J., Stuart, D., Aardalen, K., Poon, D. Acs Med.Chem.Lett.