CATH Domain 4yxsA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	cAMP-dependent protein kinase catalytic subunit

Enzyme Information

2.7.11.11

cAMP-dependent protein kinase.

based on mapping to UniProt P00517

ATP + a protein = ADP + a phosphoprotein.

-!- cAMP is required to activate this enzyme. -!- The inactive holoenzyme of cAMP-dependent protein kinase is a tetramer composed of two regulatory (R) and two catalytic (C) subunits. -!- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP molecules and two free monomeric catalytic subunits (i.e. R(2)C(2) + 4 cAMP = R(2)(cAMP)(4) + 2 C). -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P00517

KAPCA_BOVIN

Bos taurus

CAMP-dependent protein kinase catalytic subunit alpha

PDB Structure

PDB	4YXS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles. Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Bartoschek, S., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.U., Becker, S., Griesinger, C. Angew.Chem.Int.Ed.Engl.