CATH Domain 4q9zA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Protein kinase C

Enzyme Information

2.7.11.13

Protein kinase C.

based on mapping to UniProt Q04759

ATP + a protein = ADP + a phosphoprotein.

-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q04759

KPCT_HUMAN

Homo sapiens

Protein kinase C theta type

PDB Structure

PDB	4Q9Z
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Selective and Orally Bioavailable Protein Kinase C theta (PKC theta ) Inhibitors from a Fragment Hit. George, D.M., Breinlinger, E.C., Friedman, M., Zhang, Y., Wang, J., Argiriadi, M., Bansal-Pakala, P., Barth, M., Duignan, D.B., Honore, P., Lang, Q., Mittelstadt, S., Potin, D., Rundell, L., Edmunds, J.J. J.Med.Chem.