CATH Domain 4otfA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt Q06187

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q06187

BTK_HUMAN

Homo sapiens

Tyrosine-protein kinase BTK

PDB Structure

PDB	4OTF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834. Young, W.B., Barbosa, J., Blomgren, P., Bremer, M.C., Crawford, J.J., Dambach, D., Gallion, S., Hymowitz, S.G., Kropf, J.E., Lee, S.H., Liu, L., Lubach, J.W., Macaluso, J., Maciejewski, P., Maurer, B., Mitchell, S.A., Ortwine, D.F., Di Paolo, J., Reif, K., Scheerens, H., Schmitt, A., Sowell, C.G., Wang, X., Wong, H., Xiong, J.M., Xu, J., Zhao, Z., Currie, K.S. Bioorg.Med.Chem.Lett.