CATH Domain 4hvhA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P52333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52333

JAK3_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK3

PDB Structure

PDB	4HVH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models. Soth, M., Hermann, J.C., Yee, C., Alam, M., Barnett, J.W., Berry, P., Browner, M.F., Frank, K., Frauchiger, S., Harris, S., He, Y., Hekmat-Nejad, M., Hendricks, T., Henningsen, R., Hilgenkamp, R., Ho, H., Hoffman, A., Hsu, P.Y., Hu, D.Q., Itano, A., Jaime-Figueroa, S., Jahangir, A., Jin, S., Kuglstatter, A., Kutach, A.K., Liao, C., Lynch, S., Menke, J., Niu, L., Patel, V., Railkar, A., Roy, D., Shao, A., Shaw, D., Steiner, S., Sun, Y., Tan, S.L., Wang, S., Vu, M.D. J.Med.Chem.