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1 keywords

CATH Domain 3vhlA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.58 Methane Monooxygenase Hydroxylase; Chain G, domain 1
Homologous Superfamily 1.20.58.740 DOCK DHR2 domain, lobe C

Domain Context

CATH Clusters

Superfamily 1.20.58.740
Functional Family Dedicator of cytokinesis protein 7

Enzyme Information

UniProtKB Entries (2)

Q8C147
DOCK8_MOUSE
Mus musculus
Dedicator of cytokinesis protein 8
P60953
CDC42_HUMAN
Homo sapiens
Cell division control protein 42 homolog

PDB Structure

PDB 3VHL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.
Harada, Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Hanawa-Suetsugu, K., Kukimoto-Niino, M., Nishizaki, T., Shirouzu, M., Duan, X., Uruno, T., Nishikimi, A., Sanematsu, F., Yokoyama, S., Stein, J.V., Kinashi, T., Fukui, Y.
Blood
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