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1 keywords

CATH Domain 3soaA01

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.200 Phosphorylase Kinase; domain 1
Homologous Superfamily 3.30.200.20 Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Calcium/calmodulin-dependent protein kinase type II subunit delta isoform 2

Enzyme Information

2.7.11.17
Calcium/calmodulin-dependent protein kinase.
based on mapping to UniProt Q9UQM7
ATP + a protein = ADP + a phosphoprotein.
-!- Requires calmodulin. -!- A wide range of proteins can act as acceptor, including vimentin, synapsin, glycogen synthase, myosin light-chains and the microtubule- associated tau protein. -!- Not identical with EC 2.7.11.18 or EC 2.7.11.26. -!- Formerly EC 2.7.1.120 and EC 2.7.1.123.

UniProtKB Entries (1)

Q9UQM7
KCC2A_HUMAN
Homo sapiens
Calcium/calmodulin-dependent protein kinase type II subunit alpha

PDB Structure

PDB 3SOA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme.
Chao, L.H., Stratton, M.M., Lee, I.H., Rosenberg, O.S., Levitz, J., Mandell, D.J., Kortemme, T., Groves, J.T., Schulman, H., Kuriyan, J.
Cell(Cambridge,Mass.)
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