CATH Domain 3cupB01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.320	Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
	3.10.320.10	Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1

Domain Context

CATH Clusters

Superfamily	Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Functional Family	HLA class II histocompatibility antigen, DRB1-1 beta chain

Enzyme Information

4.1.1.15

Glutamate decarboxylase.

based on mapping to UniProt Q05683

L-glutamate = 4-aminobutanoate + CO(2).

-!- The brain enzyme also acts on L-cysteate, 3-sulfino-L-alanine and L-aspartate.

UniProtKB Entries (2)

P04228	HA2D_MOUSE Mus musculus H-2 class II histocompatibility antigen, A-D alpha chain
Q05683	DCE2_RAT Rattus norvegicus Glutamate decarboxylase 2

PDB Structure

PDB	3CUP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the MHC class II molecule I-Ag7 in complex with the peptide GAD221-235 Yoshida, K., Corper, A.L., Puckett, C., Sim, J., Valerie, M.-D., Jabri, B., Wilson, I.A., Teyton, L. To be Published