CATH Domain 3ctjA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	3CTJ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors Cai, Z.-W., Wei, D., Schroeder, G.M., Cornelius, L.A., Kim, K., Chen, X.-T., Schmidt, R.J., Williams, D.K., Tokarski, J.S., An, Y., Sack, J.S., Manne, V., Kamath, A., Zhang, Y., Marathe, P., Hunt, J.T., Lombardo, L.J., Fargnoli, J., Borzilleri, R.M. Bioorg.Med.Chem.Lett.