CATH Domain 2j5fA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P00533

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533

EGFR_HUMAN

Homo sapiens

Epidermal growth factor receptor

PDB Structure

PDB	2J5F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Development of Affinity Probes for Tyrosine Kinases Using Chemical Genetics. Blair, J.A., Rauh, D., Kung, C., Yun, C.-H., Fan, Q.-W., Rode, H., Zhang, C., Eck, M.J., Weiss, W.A., Shokat, K.M. Nat.Chem.Biol.