CATH Domain 1vjyA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.30

Receptor protein serine/threonine kinase.

based on mapping to UniProt P36897

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36897

TGFR1_HUMAN

Homo sapiens

TGF-beta receptor type-1

PDB Structure

PDB	1VJY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Spodoptera
Primary Citation	Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-beta Type I Receptor Inhibitors. Gellibert, F., Woolven, J., Fouchet, M.-H., Mathews, N., Goodland, H., Lovegrove, V., Laroze, A., Nguyen, V.-L., Sautet, S., Wang, R., Janson, C., Smith, W., Krysa, G., Boullay, V., De Gouville, A.-C., Huet, S., Hartley, D. J.Med.Chem.