PDB 6ne5

PDB Links
Overview

PDB Information

PDB	6NE5
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli K-12
Gene Source	Homo sapiens
Primary Citation	Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. Lee, T., Christov, P.P., Shaw, S., Tarr, J.C., Zhao, B., Veerasamy, N., Jeon, K.O., Mills, J.J., Bian, Z., Sensintaffar, J.L., Arnold, A.L., Fogarty, S.A., Perry, E., Ramsey, H.E., Cook, R.S., Hollingshead, M., Davis Millin, M., Lee, K.M., Koss, B., Budhraja, A., Opferman, J.T., Kim, K., Arteaga, C.L., Moore, W.J., Olejniczak, E.T., Savona, M.R., Fesik, S.W. J.Med.Chem.
Header	Apoptosis
Released	2018-12-17
Resolution	1.850
CATH Insert Date	21 Apr, 2019

PDB Images (9)

Image of CATH 6ne5

6ne5

PDB 6ne5

Image of CATH 6ne5A

6ne5A

PDB Chain 6ne5A

Image of CATH 6ne5B

6ne5B

PDB Chain 6ne5B

Image of CATH 6ne5C

6ne5C

PDB Chain 6ne5C

Image of CATH 6ne5D

6ne5D

PDB Chain 6ne5D

Image of CATH 6ne5A01

6ne5A01

CATH Domain 6ne5A01

Image of CATH 6ne5B01

6ne5B01

CATH Domain 6ne5B01

Image of CATH 6ne5C01

6ne5C01

CATH Domain 6ne5C01

Image of CATH 6ne5D01

6ne5D01

CATH Domain 6ne5D01

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	21 Apr, 2019	Chopped
B	21 Apr, 2019	Chopped
C	21 Apr, 2019	Chopped
D	21 Apr, 2019	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6ne5A01	22 Apr, 2019	1.10.437.10	Assigned
6ne5B01	22 Apr, 2019	1.10.437.10	Assigned
6ne5C01	22 Apr, 2019	1.10.437.10	Assigned
6ne5D01	22 Apr, 2019	1.10.437.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1
Q07820	MCL1_HUMAN	Homo sapiens	Induced myeloid leukemia cell differentiation protein Mcl-1