CATH Domain 6ne5D01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.437	Apoptosis Regulator Bcl-x
	1.10.437.10	Blc2-like

Domain Context

CATH Clusters

Superfamily	Blc2-like
Functional Family	Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

MCL1_HUMAN

Homo sapiens

Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB	6NE5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. Lee, T., Christov, P.P., Shaw, S., Tarr, J.C., Zhao, B., Veerasamy, N., Jeon, K.O., Mills, J.J., Bian, Z., Sensintaffar, J.L., Arnold, A.L., Fogarty, S.A., Perry, E., Ramsey, H.E., Cook, R.S., Hollingshead, M., Davis Millin, M., Lee, K.M., Koss, B., Budhraja, A., Opferman, J.T., Kim, K., Arteaga, C.L., Moore, W.J., Olejniczak, E.T., Savona, M.R., Fesik, S.W. J.Med.Chem.