PDB 6d5j

PDB Links
Overview

PDB Information

PDB	6D5J
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W. J. Med. Chem.
Header	Signaling Protein
Released	2018-04-19
Resolution	1.750
CATH Insert Date	23 Sep, 2018

PDB Images (8)

Image of CATH 6d5j

6d5j

PDB 6d5j

Image of CATH 6d5jA

6d5jA

PDB Chain 6d5jA

Image of CATH 6d5jB

6d5jB

PDB Chain 6d5jB

Image of CATH 6d5jC

6d5jC

PDB Chain 6d5jC

Image of CATH 6d5jA00

6d5jA00

CATH Domain 6d5jA00

Image of CATH 6d5jB01

6d5jB01

CATH Domain 6d5jB01

Image of CATH 6d5jB02

6d5jB02

CATH Domain 6d5jB02

Image of CATH 6d5jC00

6d5jC00

CATH Domain 6d5jC00

PDB Prints

PDB Chains (3)

Chain ID	Date inserted into CATH	CATH Status
A	23 Sep, 2018	Chopped
B	23 Sep, 2018	Chopped
C	23 Sep, 2018	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
6d5jA00	24 Sep, 2018	3.40.50.300	Assigned
6d5jB01	24 Sep, 2018	1.20.870.10	Assigned
6d5jB02	24 Sep, 2018	1.10.840.10	Assigned
6d5jC00	24 Sep, 2018	3.40.50.300	Assigned

UniProtKB Entries (3)

Accession	Gene ID	Taxon	Description
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas
Q07889	SOS1_HUMAN	Homo sapiens	Son of sevenless homolog 1
P01112	RASH_HUMAN	Homo sapiens	GTPase HRas