CATH Domain 6d5jB01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.870	Son of sevenless (SoS) protein; Chain S, domain 1
	1.20.870.10	Son of sevenless (SoS) protein Chain: S domain 1

Domain Context

CATH Clusters

Superfamily	Son of sevenless (SoS) protein Chain: S domain 1
Functional Family	son of sevenless homolog 1 isoform X1

Enzyme Information

UniProtKB Entries (1)

RASH_HUMAN

Homo sapiens

GTPase HRas

PDB Structure

PDB	6D5J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS. Hodges, T.R., Abbott, J.R., Little, A.J., Sarkar, D., Salovich, J.M., Howes, J.E., Akan, D.T., Sai, J., Arnold, A.L., Browning, C., Burns, M.C., Sobolik, T., Sun, Q., Beesetty, Y., Coker, J.A., Scharn, D., Stadtmueller, H., Rossanese, O.W., Phan, J., Waterson, A.G., McConnell, D.B., Fesik, S.W. J. Med. Chem.