PDB Information

PDB6CN5
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Schnute, M.E., Wennerstal, M., Alley, J., Bengtsson, M., Blinn, J.R., Bolten, C.W., Braden, T., Bonn, T., Carlsson, B., Caspers, N., Chen, M., Choi, C., Collis, L.P., Crouse, K., Farnegardh, M., Fennell, K.F., Fish, S., Flick, A.C., Goos-Nilsson, A., Gullberg, H., Harris, P.K., Heasley, S.E., Hegen, M., Hromockyj, A.E., Hu, X., Husman, B., Janosik, T., Jones, P., Kaila, N., Kallin, E., Kauppi, B., Kiefer, J.R., Knafels, J., Koehler, K., Kruger, L., Kurumbail, R.G., Kyne Jr., R.E., Li, W., Lofstedt, J., Long, S.A., Menard, C.A., Mente, S., Messing, D., Meyers, M.J., Napierata, L., Noteberg, D., Nuhant, P., Pelc, M.J., Prinsen, M.J., Rhonnstad, P., Backstrom-Rydin, E., Sandberg, J., Sandstrom, M., Shah, F., Sjoberg, M., Sundell, A., Taylor, A.P., Thorarensen, A., Trujillo, J.I., Trzupek, J.D., Unwalla, R., Vajdos, F.F., Weinberg, R.A., Wood, D.C., Xing, L., Zamaratski, E., Zapf, C.W., Zhao, Y., Wilhelmsson, A., Berstein, G.
J. Med. Chem.
HeaderSignaling Protein
Released2018-03-07
Resolution2.300
CATH Insert Date09 Sep, 2018

PDB Images (5)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 09 Sep, 2018 Chopped
B 09 Sep, 2018 Chopped

CATH Domains (2)

Domain ID Date inserted into CATH Superfamily CATH Status
6cn5A00 10 Sep, 2018 1.10.565.10 Assigned
6cn5B00 10 Sep, 2018 1.10.565.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma
P51449 RORG_HUMAN Homo sapiens Nuclear receptor ROR-gamma