CATH Domain 6cn5B00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.565	Retinoid X Receptor
	1.10.565.10	Retinoid X Receptor

Domain Context

CATH Clusters

Superfamily	Retinoid X Receptor
Functional Family	Nuclear orphan receptor ROR-beta

Enzyme Information

UniProtKB Entries (1)

RORG_HUMAN

Homo sapiens

Nuclear receptor ROR-gamma

PDB Structure

PDB	6CN5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist. Schnute, M.E., Wennerstal, M., Alley, J., Bengtsson, M., Blinn, J.R., Bolten, C.W., Braden, T., Bonn, T., Carlsson, B., Caspers, N., Chen, M., Choi, C., Collis, L.P., Crouse, K., Farnegardh, M., Fennell, K.F., Fish, S., Flick, A.C., Goos-Nilsson, A., Gullberg, H., Harris, P.K., Heasley, S.E., Hegen, M., Hromockyj, A.E., Hu, X., Husman, B., Janosik, T., Jones, P., Kaila, N., Kallin, E., Kauppi, B., Kiefer, J.R., Knafels, J., Koehler, K., Kruger, L., Kurumbail, R.G., Kyne Jr., R.E., Li, W., Lofstedt, J., Long, S.A., Menard, C.A., Mente, S., Messing, D., Meyers, M.J., Napierata, L., Noteberg, D., Nuhant, P., Pelc, M.J., Prinsen, M.J., Rhonnstad, P., Backstrom-Rydin, E., Sandberg, J., Sandstrom, M., Shah, F., Sjoberg, M., Sundell, A., Taylor, A.P., Thorarensen, A., Trujillo, J.I., Trzupek, J.D., Unwalla, R., Vajdos, F.F., Weinberg, R.A., Wood, D.C., Xing, L., Zamaratski, E., Zapf, C.W., Zhao, Y., Wilhelmsson, A., Berstein, G. J. Med. Chem.