PDB Information

PDB6CKC
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity.
Bonday, Z.Q., Cortez, G.S., Grogan, M.J., Antonysamy, S., Weichert, K., Bocchinfuso, W.P., Li, F., Kennedy, S., Li, B., Mader, M.M., Arrowsmith, C.H., Brown, P.J., Eram, M.S., Szewczyk, M.M., Barsyte-Lovejoy, D., Vedadi, M., Guccione, E., Campbell, R.M.
ACS Med Chem Lett
HeaderTransferase
Released2018-02-27
Resolution2.800
CATH Insert Date03 Jun, 2018

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 03 Jun, 2018 Chopped
B 03 Jun, 2018 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
6ckcA01 29 Jun, 2018 3.20.20.150 Assigned
6ckcA02 29 Jun, 2018 3.40.50.150 Assigned
6ckcA03 29 Jun, 2018 2.70.160.11 Assigned
6ckcB00 29 Jun, 2018 2.130.10.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
O14744 ANM5_HUMAN Homo sapiens Protein arginine N-methyltransferase 5
Q9BQA1 MEP50_HUMAN Homo sapiens Methylosome protein 50
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