PDB 6br1

PDB Information

PDB6BR1
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.
Banerjee, S., Arnst, K.E., Wang, Y., Kumar, G., Deng, S., Yang, L., Li, G.B., Yang, J., White, S.W., Li, W., Miller, D.D.
J. Med. Chem.
HeaderCell Cycle/Inhibitor
Released2017-11-29
Resolution2.300
CATH Insert Date06 Jul, 2018

PDB Images (23)

PDB Prints

PDB Chains (6)

Chain ID Date inserted into CATH CATH Status
A 06 Jul, 2018 Chopped
B 06 Jul, 2018 Chopped
C 06 Jul, 2018 Chopped
D 06 Jul, 2018 Chopped
E 06 Jul, 2018 Chopped
F 06 Jul, 2018 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
6br1A01 19 Jul, 2018 3.40.50.1440 Assigned
6br1A02 19 Jul, 2018 3.30.1330.20 Assigned
6br1A03 19 Jul, 2018 1.10.287.600 Assigned
6br1B01 19 Jul, 2018 3.40.50.1440 Assigned
6br1B02 19 Jul, 2018 3.30.1330.20 Assigned
6br1B03 19 Jul, 2018 1.10.287.600 Assigned
6br1C01 19 Jul, 2018 3.40.50.1440 Assigned
6br1C02 19 Jul, 2018 3.30.1330.20 Assigned
6br1C03 19 Jul, 2018 1.10.287.600 Assigned
6br1D01 19 Jul, 2018 3.40.50.1440 Assigned
6br1D02 19 Jul, 2018 3.30.1330.20 Assigned
6br1D03 19 Jul, 2018 1.10.287.600 Assigned
6br1E01 19 Jul, 2018 6.10.280.30 Assigned
6br1F01 19 Jul, 2018 3.40.50.11480 Assigned
6br1F02 19 Jul, 2018 3.30.470.20 Assigned
6br1F03 19 Jul, 2018 3.30.1490.20 Assigned

UniProtKB Entries (6)

Accession Gene ID Taxon Description
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
E1BQ43 E1BQ43_CHICK Gallus gallus Uncharacterized protein
P02554 TBB_PIG Sus scrofa Tubulin beta chain
P02554 TBB_PIG Sus scrofa Tubulin beta chain
Q9H169 STMN4_HUMAN Homo sapiens Stathmin-4
Q2XVP4 TBA1B_PIG Sus scrofa Tubulin alpha-1B chain
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