PDB Information

PDB5V7I
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker, G.S., Ghergurovich, J.M., Mainolfi, N., Suri, V., Jeong, S.K., Hsin-Jung Li, S., Friedman, A., Manfredi, M.G., Gitai, Z., Kim, H., Rabinowitz, J.D.
Proc. Natl. Acad. Sci. U.S.A.
HeaderTransferase/Transferase Inhibitor
Released2017-03-20
Resolution2.470
CATH Insert Date14 Nov, 2017

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 14 Nov, 2017 Chopped
B 14 Nov, 2017 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5v7iA01 10 Dec, 2017 3.40.640.10 Assigned
5v7iA02 10 Dec, 2017 3.90.1150.10 Assigned
5v7iB01 10 Dec, 2017 3.40.640.10 Assigned
5v7iB02 10 Dec, 2017 3.90.1150.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P34897 GLYM_HUMAN Homo sapiens Serine hydroxymethyltransferase, mitochondrial
P34897 GLYM_HUMAN Homo sapiens Serine hydroxymethyltransferase, mitochondrial
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