CATH Domain 5v7iA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family	Serine hydroxymethyltransferase

Enzyme Information

2.1.2.1

Glycine hydroxymethyltransferase.

based on mapping to UniProt P34897

5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.

-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

P34897

GLYM_HUMAN

Homo sapiens

Serine hydroxymethyltransferase, mitochondrial

PDB Structure

PDB	5V7I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Ducker, G.S., Ghergurovich, J.M., Mainolfi, N., Suri, V., Jeong, S.K., Hsin-Jung Li, S., Friedman, A., Manfredi, M.G., Gitai, Z., Kim, H., Rabinowitz, J.D. Proc. Natl. Acad. Sci. U.S.A.