PDB 5u62

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Overview

PDB Information

PDB	5U62
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli K-12
Gene Source	Homo sapiens
Primary Citation	Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. Lingel, A., Sendzik, M., Huang, Y., Shultz, M.D., Cantwell, J., Dillon, M.P., Fu, X., Fuller, J., Gabriel, T., Gu, J., Jiang, X., Li, L., Liang, F., McKenna, M., Qi, W., Rao, W., Sheng, X., Shu, W., Sutton, J., Taft, B., Wang, L., Zeng, J., Zhang, H., Zhang, M., Zhao, K., Lindvall, M., Bussiere, D.E. J. Med. Chem.
Header	Transcription/Transferase
Released	2016-12-07
Resolution	1.900
CATH Insert Date	07 May, 2017

PDB Images (7)

Image of CATH 5u62

5u62

PDB 5u62

Image of CATH 5u62A

5u62A

PDB Chain 5u62A

Image of CATH 5u62B

5u62B

PDB Chain 5u62B

Image of CATH 5u62C

5u62C

PDB Chain 5u62C

Image of CATH 5u62D

5u62D

PDB Chain 5u62D

Image of CATH 5u62A00

5u62A00

CATH Domain 5u62A00

Image of CATH 5u62B00

5u62B00

CATH Domain 5u62B00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	08 May, 2017	Chopped
B	08 May, 2017	Chopped
C	08 May, 2017	Rejected
D	08 May, 2017	Rejected

CATH Domains (2)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5u62A00	14 Dec, 2017	2.130.10.10	Assigned
5u62B00	14 Dec, 2017	2.130.10.10	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
O75530	EED_HUMAN	Homo sapiens	Polycomb protein EED
Q15910	EZH2_HUMAN	Homo sapiens	Histone-lysine N-methyltransferase EZH2
O75530	EED_HUMAN	Homo sapiens	Polycomb protein EED
Q15910	EZH2_HUMAN	Homo sapiens	Histone-lysine N-methyltransferase EZH2