CATH Domain 5u62B00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	Polycomb protein eed

Enzyme Information

UniProtKB Entries (1)

EZH2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase EZH2

PDB Structure

PDB	5U62
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. Lingel, A., Sendzik, M., Huang, Y., Shultz, M.D., Cantwell, J., Dillon, M.P., Fu, X., Fuller, J., Gabriel, T., Gu, J., Jiang, X., Li, L., Liang, F., McKenna, M., Qi, W., Rao, W., Sheng, X., Shu, W., Sutton, J., Taft, B., Wang, L., Zeng, J., Zhang, H., Zhang, M., Zhao, K., Lindvall, M., Bussiere, D.E. J. Med. Chem.