PDB Information

PDB5TPA
MethodX-RAY DIFFRACTION
Host OrganismSpodoptera frugiperda
Gene SourceHomo sapiens
Primary Citation
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
Villemure, E., Volgraf, M., Jiang, Y., Wu, G., Ly, C.Q., Yuen, P.W., Lu, A., Luo, X., Liu, M., Zhang, S., Lupardus, P.J., Wallweber, H.J., Liederer, B.M., Deshmukh, G., Plise, E., Tay, S., Wang, T.M., Hanson, J.E., Hackos, D.H., Scearce-Levie, K., Schwarz, J.B., Sellers, B.D.
ACS Med Chem Lett
HeaderTransport Protein
Released2016-10-20
Resolution2.480
CATH Insert Date04 Dec, 2016

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 05 Dec, 2016 Chopped
B 05 Dec, 2016 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
5tpaA01 10 Dec, 2016 3.40.190.10 Assigned
5tpaA02 10 Dec, 2016 3.40.190.10 Assigned
5tpaB01 10 Dec, 2016 3.40.190.10 Assigned
5tpaB02 10 Dec, 2016 3.40.190.10 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
Q05586 NMDZ1_HUMAN Homo sapiens Glutamate receptor ionotropic, NMDA 1
Q12879 NMDE1_HUMAN Homo sapiens Glutamate receptor ionotropic, NMDA 2A