PDB 5nw2
PDB Information
| PDB | 5NW2 |
| Method | X-RAY DIFFRACTION |
| Host Organism | Escherichia coli |
| Gene Source | Homo sapiens |
| Primary Citation | Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
J. Med. Chem.
|
| Header | Ligase |
| Released | 2017-05-04 |
| Resolution | 2.200 |
| CATH Insert Date | 14 Nov, 2017 |
PDB Images (29)
5nw2
PDB 5nw2
5nw2A
PDB Chain 5nw2A
5nw2B
PDB Chain 5nw2B
5nw2C
PDB Chain 5nw2C
5nw2D
PDB Chain 5nw2D
5nw2E
PDB Chain 5nw2E
5nw2F
PDB Chain 5nw2F
5nw2G
PDB Chain 5nw2G
5nw2H
PDB Chain 5nw2H
5nw2I
PDB Chain 5nw2I
5nw2J
PDB Chain 5nw2J
5nw2K
PDB Chain 5nw2K
5nw2L
PDB Chain 5nw2L
5nw2A00
CATH Domain 5nw2A00
5nw2B00
CATH Domain 5nw2B00
5nw2C01
CATH Domain 5nw2C01
5nw2C02
CATH Domain 5nw2C02
5nw2D00
CATH Domain 5nw2D00
5nw2E00
CATH Domain 5nw2E00
5nw2F01
CATH Domain 5nw2F01
5nw2F02
CATH Domain 5nw2F02
5nw2G00
CATH Domain 5nw2G00
5nw2H00
CATH Domain 5nw2H00
5nw2I01
CATH Domain 5nw2I01
5nw2I02
CATH Domain 5nw2I02
5nw2J00
CATH Domain 5nw2J00
5nw2K00
CATH Domain 5nw2K00
5nw2L01
CATH Domain 5nw2L01
5nw2L02
CATH Domain 5nw2L02
PDB Prints
PDB Chains (12)
| Chain ID | Date inserted into CATH | CATH Status |
|---|---|---|
| A | 14 Nov, 2017 | Chopped |
| B | 14 Nov, 2017 | Chopped |
| C | 14 Nov, 2017 | Chopped |
| D | 14 Nov, 2017 | Chopped |
| E | 14 Nov, 2017 | Chopped |
| F | 14 Nov, 2017 | Chopped |
| G | 14 Nov, 2017 | Chopped |
| H | 14 Nov, 2017 | Chopped |
| I | 14 Nov, 2017 | Chopped |
| J | 14 Nov, 2017 | Chopped |
| K | 14 Nov, 2017 | Chopped |
| L | 14 Nov, 2017 | Chopped |
CATH Domains (16)
| Domain ID | Date inserted into CATH | Superfamily | CATH Status |
|---|---|---|---|
| 5nw2A00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nw2B00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nw2C01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nw2C02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nw2D00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nw2E00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nw2F01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nw2F02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nw2G00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nw2H00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nw2I01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nw2I02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
| 5nw2J00 | 10 Dec, 2017 | 3.10.20.90 | Assigned |
| 5nw2K00 | 10 Dec, 2017 | 3.30.710.10 | Assigned |
| 5nw2L01 | 10 Dec, 2017 | 2.60.40.780 | Assigned |
| 5nw2L02 | 10 Dec, 2017 | 1.10.750.10 | Assigned |
UniProtKB Entries (12)
| Accession | Gene ID | Taxon | Description |
|---|---|---|---|
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| P40337 | VHL_HUMAN | Homo sapiens | von Hippel-Lindau disease tumor suppressor |
| Q15369 | ELOC_HUMAN | Homo sapiens | Elongin-C |
| Q15370 | ELOB_HUMAN | Homo sapiens | Elongin-B |
