CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.40 | Immunoglobulin-like |
|
2.60.40.780 | von Hippel-Lindau disease tumour suppressor, beta domain |
Domain Context
CATH Clusters
| Superfamily | von Hippel-Lindau disease tumour suppressor, beta domain |
| Functional Family | von Hippel-Lindau disease tumor suppressor |
Enzyme Information
UniProtKB Entries (1)
| Q15370 |
ELOB_HUMAN
Homo sapiens
Elongin-B
|
PDB Structure
| PDB | 5NW2 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298).
J. Med. Chem.
|