CATH Domain 5nw2L01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.780	von Hippel-Lindau disease tumour suppressor, beta domain

Domain Context

CATH Clusters

Superfamily	von Hippel-Lindau disease tumour suppressor, beta domain
Functional Family	von Hippel-Lindau disease tumor suppressor

Enzyme Information

UniProtKB Entries (1)

ELOB_HUMAN

Homo sapiens

Elongin-B

PDB Structure

PDB	5NW2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298). Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A. J. Med. Chem.