PDB 5lli

PDB Information

PDB5LLI
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Potent and selective chemical probe of hypoxic signalling downstream of HIF-alpha hydroxylation via VHL inhibition.
Frost, J., Galdeano, C., Soares, P., Gadd, M.S., Grzes, K.M., Ellis, L., Epemolu, O., Shimamura, S., Bantscheff, M., Grandi, P., Read, K.D., Cantrell, D.A., Rocha, S., Ciulli, A.
Nat Commun
HeaderLigase
Released2016-07-27
Resolution2.400
CATH Insert Date20 Nov, 2016

PDB Images (29)

PDB Prints

PDB Chains (12)

Chain ID Date inserted into CATH CATH Status
A 21 Nov, 2016 Chopped
B 21 Nov, 2016 Chopped
C 21 Nov, 2016 Chopped
D 21 Nov, 2016 Chopped
E 21 Nov, 2016 Chopped
F 21 Nov, 2016 Chopped
G 21 Nov, 2016 Chopped
H 21 Nov, 2016 Chopped
I 21 Nov, 2016 Chopped
J 21 Nov, 2016 Chopped
K 21 Nov, 2016 Chopped
L 21 Nov, 2016 Chopped

CATH Domains (16)

Domain ID Date inserted into CATH Superfamily CATH Status
5lliA00 25 Nov, 2016 3.10.20.90 Assigned
5lliB00 25 Nov, 2016 3.30.710.10 Assigned
5lliC01 24 Nov, 2016 2.60.40.780 Assigned
5lliC02 24 Nov, 2016 1.10.750.10 Assigned
5lliD00 25 Nov, 2016 3.10.20.90 Assigned
5lliE00 25 Nov, 2016 3.30.710.10 Assigned
5lliF01 25 Nov, 2016 2.60.40.780 Assigned
5lliF02 25 Nov, 2016 1.10.750.10 Assigned
5lliG00 25 Nov, 2016 3.10.20.90 Assigned
5lliH00 24 Nov, 2016 3.30.710.10 Assigned
5lliI01 25 Nov, 2016 2.60.40.780 Assigned
5lliI02 25 Nov, 2016 1.10.750.10 Assigned
5lliJ00 24 Nov, 2016 3.10.20.90 Assigned
5lliK00 25 Nov, 2016 3.30.710.10 Assigned
5lliL01 25 Nov, 2016 2.60.40.780 Assigned
5lliL02 25 Nov, 2016 1.10.750.10 Assigned

UniProtKB Entries (12)

Accession Gene ID Taxon Description
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
Q15370 ELOB_HUMAN Homo sapiens Elongin-B
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
P40337 VHL_HUMAN Homo sapiens von Hippel-Lindau disease tumor suppressor
Q15369 ELOC_HUMAN Homo sapiens Elongin-C
Q15370 ELOB_HUMAN Homo sapiens Elongin-B