PDB 5i8g

PDB Information

PDB5I8G
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Taylor, A.M., Cote, A., Hewitt, M.C., Pastor, R., Leblanc, Y., Nasveschuk, C.G., Romero, F.A., Crawford, T.D., Cantone, N., Jayaram, H., Setser, J., Murray, J., Beresini, M.H., de Leon Boenig, G., Chen, Z., Conery, A.R., Cummings, R.T., Dakin, L.A., Flynn, E.M., Huang, O.W., Kaufman, S., Keller, P.J., Kiefer, J.R., Lai, T., Li, Y., Liao, J., Liu, W., Lu, H., Pardo, E., Tsui, V., Wang, J., Wang, Y., Xu, Z., Yan, F., Yu, D., Zawadzke, L., Zhu, X., Zhu, X., Sims, R.J., Cochran, A.G., Bellon, S., Audia, J.E., Magnuson, S., Albrecht, B.K.
Acs Med.Chem.Lett.
HeaderTranscription/Protein Binding
Released2016-02-18
Resolution1.410
CATH Insert Date24 Apr, 2016

PDB Images (5)

PDB Prints

PDB Chains (1)

Chain ID Date inserted into CATH CATH Status
A 25 Apr, 2016 Chopped

CATH Domains (3)

Domain ID Date inserted into CATH Superfamily CATH Status
5i8gA01 16 Jan, 2018 1.20.920.10 Assigned
5i8gA02 16 Jan, 2018 3.30.40.10 Assigned
5i8gA03 16 Jan, 2018 2.10.110.40 Assigned

UniProtKB Entries (1)

Accession Gene ID Taxon Description
Q92793 CBP_HUMAN Homo sapiens CREB-binding protein