1 keywords

CATH Domain 5i8gA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.40 Herpes Virus-1
Homologous Superfamily 3.30.40.10 Zinc/RING finger domain, C3HC4 (zinc finger)

Domain Context

CATH Clusters

Superfamily Zinc/RING finger domain, C3HC4 (zinc finger)
Functional Family Histone acetyltransferase p300

Enzyme Information

2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt Q92793
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

Q92793
CBP_HUMAN
Homo sapiens
CREB-binding protein

PDB Structure

PDB 5I8G
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).
Taylor, A.M., Cote, A., Hewitt, M.C., Pastor, R., Leblanc, Y., Nasveschuk, C.G., Romero, F.A., Crawford, T.D., Cantone, N., Jayaram, H., Setser, J., Murray, J., Beresini, M.H., de Leon Boenig, G., Chen, Z., Conery, A.R., Cummings, R.T., Dakin, L.A., Flynn, E.M., Huang, O.W., Kaufman, S., Keller, P.J., Kiefer, J.R., Lai, T., Li, Y., Liao, J., Liu, W., Lu, H., Pardo, E., Tsui, V., Wang, J., Wang, Y., Xu, Z., Yan, F., Yu, D., Zawadzke, L., Zhu, X., Zhu, X., Sims, R.J., Cochran, A.G., Bellon, S., Audia, J.E., Magnuson, S., Albrecht, B.K.
Acs Med.Chem.Lett.