PDB 5fi4

PDB Links
Overview

PDB Information

PDB	5FI4
Method	X-RAY DIFFRACTION
Host Organism	Spodoptera frugiperda
Gene Source	Homo sapiens
Primary Citation	Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Han, W., Menezes, D.L., Xu, Y., Knapp, M.S., Elling, R., Burger, M.T., Ni, Z.J., Smith, A., Lan, J., Williams, T.E., Verhagen, J., Huh, K., Merritt, H., Chan, J., Kaufman, S., Voliva, C.F., Pecchi, S. Bioorg.Med.Chem.Lett.
Header	Transferase/Transferase Inhibitor
Released	2015-12-22
Resolution	2.500
CATH Insert Date	10 Apr, 2016

PDB Images (10)

Image of CATH 5fi4

5fi4

PDB 5fi4

Image of CATH 5fi4A

5fi4A

PDB Chain 5fi4A

Image of CATH 5fi4B

5fi4B

PDB Chain 5fi4B

Image of CATH 5fi4A01

5fi4A01

CATH Domain 5fi4A01

Image of CATH 5fi4A02

5fi4A02

CATH Domain 5fi4A02

Image of CATH 5fi4A03

5fi4A03

CATH Domain 5fi4A03

Image of CATH 5fi4A04

5fi4A04

CATH Domain 5fi4A04

Image of CATH 5fi4A05

5fi4A05

CATH Domain 5fi4A05

Image of CATH 5fi4B01

5fi4B01

CATH Domain 5fi4B01

Image of CATH 5fi4B02

5fi4B02

CATH Domain 5fi4B02

PDB Prints

PDB Chains (2)

Chain ID	Date inserted into CATH	CATH Status
A	11 Apr, 2016	Chopped
B	11 Apr, 2016	Chopped

CATH Domains (7)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
5fi4A01	12 Jul, 2018	3.10.20.770	Assigned
5fi4A02	12 Jul, 2018	2.60.40.150	Assigned
5fi4A03	12 Jul, 2018	1.25.40.70	Assigned
5fi4A04	12 Jul, 2018	3.30.1010.10	Assigned
5fi4A05	12 Jul, 2018	1.10.1070.11	Assigned
5fi4B01	14 Nov, 2017		Holding pen
5fi4B02	14 Nov, 2017	1.10.287.1490	Assigned

UniProtKB Entries (2)

Accession	Gene ID	Taxon	Description
P27986	P85A_HUMAN	Homo sapiens	Phosphatidylinositol 3-kinase regulatory subunit alpha
P42336	PK3CA_HUMAN	Homo sapiens	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform