CATH Domain 5fi4B02

Superfamily	1.10.287.1490
Functional Family	Putative phosphatidylinositol 3-kinase regulatory subunit alpha

PK3CA_HUMAN

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

PDB	5FI4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model. Han, W., Menezes, D.L., Xu, Y., Knapp, M.S., Elling, R., Burger, M.T., Ni, Z.J., Smith, A., Lan, J., Williams, T.E., Verhagen, J., Huh, K., Merritt, H., Chan, J., Kaufman, S., Voliva, C.F., Pecchi, S. Bioorg.Med.Chem.Lett.