PDB Information

PDB4JNM
MethodX-RAY DIFFRACTION
Host OrganismEscherichia coli
Gene SourceHomo sapiens
Primary Citation
Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y.C., Kley, N., Liang, X., Liederer, B.M., Lin, J., Mukadam, S., O'Brien, T., Oh, A., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Sodhi, J., Wang, W., Wang, Z., Xiao, Y., Yuen, P.W., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S.
Bioorg.Med.Chem.Lett.
HeaderTransferase/Transferase Inhibitor
Released2013-03-15
Resolution2.200
CATH Insert Date07 Jul, 2013

PDB Images (7)

PDB Prints

PDB Chains (2)

Chain ID Date inserted into CATH CATH Status
A 08 Jul, 2013 Chopped
B 08 Jul, 2013 Chopped

CATH Domains (4)

Domain ID Date inserted into CATH Superfamily CATH Status
4jnmA01 09 Aug, 2013 Holding pen
4jnmA02 09 Aug, 2013 3.20.20.70 Assigned
4jnmB01 09 Aug, 2013 Holding pen
4jnmB02 09 Aug, 2013 3.20.20.70 Assigned

UniProtKB Entries (2)

Accession Gene ID Taxon Description
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
P43490 NAMPT_HUMAN Homo sapiens Nicotinamide phosphoribosyltransferase
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