Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.
Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y.C., Kley, N., Liang, X., Liederer, B.M., Lin, J., Mukadam, S., O'Brien, T., Oh, A., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Sodhi, J., Wang, W., Wang, Z., Xiao, Y., Yuen, P.W., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S.
Bioorg.Med.Chem.Lett.