CATH Domain 4jnmB02

Superfamily	Aldolase class I
Functional Family

2.4.2.12

Nicotinamide phosphoribosyltransferase.

based on mapping to UniProt P43490

Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

NAMPT_HUMAN

Homo sapiens

Nicotinamide phosphoribosyltransferase

PDB	4JNM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Gunzner-Toste, J., Zhao, G., Bauer, P., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Fu, B., Han, B., Ho, Y.C., Kley, N., Liang, X., Liederer, B.M., Lin, J., Mukadam, S., O'Brien, T., Oh, A., Reynolds, D.J., Sharma, G., Skelton, N., Smith, C.C., Sodhi, J., Wang, W., Wang, Z., Xiao, Y., Yuen, P.W., Zak, M., Zhang, L., Zheng, X., Bair, K.W., Dragovich, P.S. Bioorg.Med.Chem.Lett.