PDB 3tfq

PDB Links
Overview

PDB Information

PDB	3TFQ
Method	X-RAY DIFFRACTION
Host Organism	Escherichia coli
Gene Source	Homo sapiens
Primary Citation	Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1) Wu, S.C., Yoon, D., Chin, J., van Kirk, K., Seethala, R., Golla, R., He, B., Harrity, T., Kunselman, L.K., Morgan, N.N., Ponticiello, R.P., Taylor, J.R., Zebo, R., Harper, T.W., Li, W., Wang, M., Zhang, L., Sleczka, B.G., Nayeem, A., Sheriff, S., Camac, D.M., Morin, P.E., Everlof, J.G., Li, Y.X., Ferraro, C.A., Kieltyka, K., Shou, W., Vath, M.B., Zvyaga, T.A., Gordon, D.A., Robl, J.A. Bioorg.Med.Chem.Lett.
Header	Oxidoreductase/Oxidoreductase Inhibitor
Released	2011-08-16
Resolution	1.800
CATH Insert Date	06 Nov, 2011

PDB Images (9)

Image of CATH 3tfq

3tfq

PDB 3tfq

Image of CATH 3tfqA

3tfqA

PDB Chain 3tfqA

Image of CATH 3tfqB

3tfqB

PDB Chain 3tfqB

Image of CATH 3tfqD

3tfqD

PDB Chain 3tfqD

Image of CATH 3tfqE

3tfqE

PDB Chain 3tfqE

Image of CATH 3tfqA00

3tfqA00

CATH Domain 3tfqA00

Image of CATH 3tfqB01

3tfqB01

CATH Domain 3tfqB01

Image of CATH 3tfqD01

3tfqD01

CATH Domain 3tfqD01

Image of CATH 3tfqE00

3tfqE00

CATH Domain 3tfqE00

PDB Prints

PDB Chains (4)

Chain ID	Date inserted into CATH	CATH Status
A	29 Nov, 2011	Chopped
B	29 Nov, 2011	Chopped
D	29 Nov, 2011	Chopped
E	29 Nov, 2011	Chopped

CATH Domains (4)

Domain ID	Date inserted into CATH	Superfamily	CATH Status
3tfqA00	01 Dec, 2011	3.40.50.720	Assigned
3tfqB01	01 Dec, 2011	3.40.50.720	Assigned
3tfqD01	01 Dec, 2011	3.40.50.720	Assigned
3tfqE00	01 Dec, 2011	3.40.50.720	Assigned

UniProtKB Entries (4)

Accession	Gene ID	Taxon	Description
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1
P28845	DHI1_HUMAN	Homo sapiens	Corticosteroid 11-beta-dehydrogenase isozyme 1